Historically, clomid has been used since the 1960′s to help females with infrequent menstruation. Thereafter, its use expanded to include fertility issues in females. In 1989, a patent was awarded to Yale University medical researchers to predict fertility in women with the help of clomiphene citrate.
Most anabolic steroids, especially the androgens, cause inhibition of the body’s own testosterone production. When a bodybuilder comes off a steroid cycle, natural testosterone production is zero and the levels of the steroids taken in the blood are diminishing. This leaves the ratios of catabolic : anabolic hormones in the blood high, hence the body is in a state of catabolism, and, as a result, much of the muscle tissue that was gained on the cycle is now going to be lost.
In certain tissues, it can block the ability of Estrogen to bind with it’s receptor. This blocks Estrogen’s negative feedback effect on the HPTA (Hypothalamus-Pituitary-Testicular Axis) in men, or HPOA (Hypothalamus-Pituitary-Ovarian Axis) in women. This results in the release of Leutinizing Hormone and Follicle Stimulating Hormone. For men this means an increase in natural Testosterone Production. In women this will result in inducing ovulation.